SEC S20W2 || Hemoglobin - Module 2

---

Assalamualaikum steemians

---

Source

---

Rafael Rangel death

---

Rafael Rangel was a famous Venezuelan physician who died on July 20th 1927, due to suicide when he started his experiment with hookworm.He committed suicide because he lost his life in his intentions.After experiment it leads to anemia which decrease albumin level.Hence it caused dehydration and then cardiac failure.

In Rangel's death first acute level of intestinal hookworm infection occured which caused a secondary bacterial infection and then hemorrhagic shock.He is also recognized as a medical martyr in medicine world as because of his experiment many people made hemoglobin , hookworm and anemia researches.

---

Hemoglobin

---

Hemoglobin is a protein structure in red blood cells that carries O2 and CO2 in whole body.

Structure wise

• Made up of four polypeptide chains (2 alpha, 2 beta)
• Each chain contains one heme group with iron

Functions

• Transportation of oxygen from lungs towards our body tissues.
• Transportation of carbon dioxide from body tissues towards lungs
• Regulation and maintainence of pH levels
• Maintainance of blood oxygen binding capacity

Importance

• Most important for survival of life
• Most important for energy production
• Maintaining healthy body tissues and organs

---

Automated and Manual hematocrit

---

Here's a table comparing Automated Hematocrit and Manual Hematocrit:

Properties	Automated Hematocrit	Manual Hematocrit
1. Accuracy	Less precise	More precise
2. Speed	High speed	15-30 minutes
3. Cost	More initial investment	Less equipment cost
4. Maintenance	Regular maintaining	Minimal maintenance
5. Operator Skill	Less training	Proper technician
6. Sample Volume	Little sample volume	Greater sample volume
8. Quality Control	Great quality control	Manual quality checks

Benefits of Automated

• More accuracy
• Efficient results
• Enhanced efficiency

Benefits of Manual

• Cost-friendly
• Much portable
• Good for small labs

---

Real life hematocrit example

---

I am going to explain an example of Flour-to-Water Ratio in Cookie Dough.

Suppose that while making cookie dough you are taking Flour (Red Blood Cells) = 40% and Water (Plasma) = 60% so here in this example flour is representing red blood cells while water is representing plasma (the liquid portion of blood)

Hematocrit = 40%

Because here in this real life example Hematocrit is measuring quantity of flour (RBCs) in total dough mixture.

Suppose three different scenarios for better understanding!

Scenario 1: Normal dough

• 40% flour (RBCs)
• 60% water (plasma)

Scenario 2: Dry Dough (Increased Hct)

• 50% flour (RBCs)
• 50% water (plasma)

If there is dry dough then less water would concentrates the flour (RBCs)which would increase hematocrit.

Scenario 3: Runny Dough (Decreased Hct)

• 30% flour (RBCs)
• 70% water (plasma)

If there is runny dough, then too much water would dilute flour (RBCs) and will decrease hematocrit.

Source

---

Hemoglobin module-2 quiz?

---

Done	✅
Score	8/10

---

I want to invite @kouba01,@malikusman1,@simonnwigwe