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Medically Reviewed by Dr. Paul Hetrick, PharmD
由药学博士 Paul Hetrick 博士进行医学审查
Last Updated: January 19, 2024
最后更新： 2024 年 1 月 19 日
Can Fenbendazole Be Used to Treat Pancreatic Cancer?
芬苯达唑可以用于治疗胰腺癌吗？
Dr. Paul Hetrick
Medically Reviewed by Dr. Paul Hetrick, PharmD
由药学博士 Paul Hetrick 博士进行医学审查
Dr. Paul Hetrick is a licensed pharmacist with extensive professional experience across various fields.
Paul Hetrick 博士是一位执业药剂师，在各个领域拥有丰富的专业经验。
He currently resides and practices in North Carolina. Dr. Hetrick earned his BS in Biology from the University of North Carolina at Chapel Hill and his PharmD from Campbell University College of Pharmacy & Health Sciences. He holds several certifications, including a license as a pharmacist and a Pharmacy-Based Immunization Delivery Certification.
他目前在北卡罗来纳州居住和执业。 Hetrick 博士在北卡罗来纳大学教堂山分校获得生物学学士学位，在坎贝尔大学药学与健康科学学院获得药学博士学位。他拥有多项认证，包括药剂师执照和基于药房的免疫接种认证。
Dr. Hetrick is affiliated with the American Pharmacists Association (APhA) and the North Carolina Association of Pharmacists (NCAP).
Hetrick 博士隶属于美国药剂师协会 (APhA) 和北卡罗来纳州药剂师协会 (NCAP)。
Fenbendazole is a broad-spectrum anthelmintic medicine primarily used to treat gastrointestinal parasites such as roundworms, hookworms, and some tapeworms in animals
芬苯达唑是一种广谱驱虫药，主要用于治疗动物胃肠道寄生虫，如蛔虫、钩虫和某些绦虫
In recent years, scientific studies have shown that it can also inhibit cancer cells and stop them from growing. It does this by affecting how cells work, like inhibiting glucose uptake or disrupting certain structures inside the cancer cells
近年来科学研究表明，它还可以抑制癌细胞并阻止其生长。它通过影响细胞的工作方式来实现这一点，例如抑制葡萄糖摄取或破坏癌细胞内的某些结构
Although the research is still limited, some scientists interested in repurposing fenbendazole have turned their attention specifically to its effects on pancreatic cancer, one of the deadliest forms of the disease. Recent statistics show only about 10% percent of patients diagnosed with pancreatic cancer survive for five years.
尽管研究仍然有限，但一些对重新利用芬苯达唑感兴趣的科学家已将注意力转向其对胰腺癌的影响，胰腺癌是最致命的疾病之一。最近的统计数据显示，诊断为胰腺癌的患者中只有约 10% 能存活五年。
Despite the initial effectiveness of certain chemotherapies, pancreatic tumors frequently develop resistance to these treatments. Moreover, newer methods like immunotherapy have struggled to address this challenging disease effectively. All of which has led researchers to turn their attention to Fenbendazole as a possible treatment. And while there is a great need for further studies, early evidence is showing great promise.
尽管某些化疗最初有效，但胰腺肿瘤经常对这些治疗产生耐药性。此外，免疫疗法等新方法一直难以有效解决这种具有挑战性的疾病。所有这些导致研究人员将注意力转向芬苯达唑作为一种可能的治疗方法。尽管还需要进一步研究，但早期证据显示出巨大的希望。
Watch the Video: Is Fenbendazole Safe for Humans?
观看视频：芬苯达唑对人类安全吗？
fenben
How Fenbendazole Fights Cancer: Mechanisms of Action
芬苯达唑如何抗癌：作用机制
From what we know so far, fenbendazole is able to kill cancer cells in three different ways:
据我们目前所知，芬苯达唑能够通过三种不同的方式杀死癌细胞：
By breaking down the microtubules that support the structure of cancer cells, preventing their rapid division and multiplication.
通过破坏支持癌细胞结构的微管，防止其快速分裂和增殖。
By disrupting how cancer cells handle sugar, which they need to survive.
通过破坏癌细胞处理糖的方式，这是它们生存所需的。
By increasing the activity of a gene called p53, known for fighting cancer. Some cancer patients lack this gene or have a mutated version, allowing cancer cells to grow unchecked.
通过增加 p53 基因的活性，该基因以抗癌而闻名。一些癌症患者缺乏这种基因或有突变版本，导致癌细胞不受控制地生长。
These proposed mechanisms are based on animal data. More research, including human clinical trials, is needed to show that fenbendazole is safe and effective for use in cancer treatment.
这些提出的机制基于动物数据。需要更多的研究，包括人体临床试验，来证明芬苯达唑用于癌症治疗是安全有效的。
The cancer cells in pancreatic cancer behave in a very specific way when it comes to getting energy and nutrients for their growth. They use special ways to process glucose, amino acids, and lipids, which helps them grow and spread quickly. Scientists believe that the key to using fenbendazole effectively in treating pancreatic cancer lies in figuring out how the drug targets the behavior of these cancer cells.
胰腺癌中的癌细胞在获取生长所需的能量和营养时以非常特殊的方式表现。它们使用特殊的方式来处理葡萄糖、氨基酸和脂质，这有助于它们快速生长和传播。科学家认为，有效使用芬苯达唑治疗胰腺癌的关键在于弄清楚该药物如何针对这些癌细胞的行为。
While fenbendazole shows promise, it’s important to consider a range of treatment options for pancreatic cancer. For a more comprehensive overview, see our article on Best Alternative Treatments for Pancreatic Cancer>>
虽然芬苯达唑显示出良好的前景，但重要的是要考虑一系列胰腺癌的治疗选择。如需更全面的概述，请参阅我们关于胰腺癌最佳替代治疗>> 的文章
Fenbendazole Vs. Other Antiparasitic Drugs in Cancer Treatment
芬苯达唑对比。癌症治疗中的其他抗寄生虫药物
Fenbendazole isn’t the only antiparasitic drug showing promise in fighting pancreatic cancer. Two other drugs – Mebendazole and Ivermectin – are also being studied for their effects on the devastating disease.
芬苯达唑并不是唯一一种有望对抗胰腺癌的抗寄生虫药物。另外两种药物——甲苯咪唑和伊维菌素——也正在研究它们对这种毁灭性疾病的影响。
Mebendazole is from the same class of medication as Fenbendazole. In early pancreatic cancer models, mebendazole treatment led to reduced inflammation and dysplasia. In more advanced stages, it also lowered tumor size, lessened advanced tumors, and decreased metastasis. In 2021, a Johns Hopkins University School of Medicine study used two different mouse models to determine that Mebendazole could slow or stop the growth and spread of both early and late-stage pancreatic cancer.
甲苯达唑与芬苯达唑属于同一类药物。在早期胰腺癌模型中，甲苯咪唑治疗可减少炎症和发育不良。在更晚期阶段，它还可以降低肿瘤大小、缩小晚期肿瘤并减少转移。 2021 年，约翰霍普金斯大学医学院的一项研究使用两种不同的小鼠模型来确定甲苯咪唑可以减缓或阻止早期和晚期胰腺癌的生长和扩散。
Ivermectin, on the other hand, belongs to a different class of drugs called Avermectins. As an antiparasitic drug, it works by affecting the nervous system of parasites, causing paralysis and death.
另一方面，伊维菌素属于不同类别的药物，称为阿维菌素。作为一种抗寄生虫药，它通过影响寄生虫的神经系统起作用，导致瘫痪和死亡。
In terms of cancer, ivermectin hinders the growth of cancer cells and their spread to other parts of the body, encourages the natural death of cancer cells, blocks the development of tumor stem cells, and can even overturn resistance to multiple drugs.
在癌症方面，伊维菌素可以阻碍癌细胞的生长及其向身体其他部位的扩散，鼓励癌细胞自然死亡，阻断肿瘤干细胞的发育，甚至可以推翻多种药物的耐药性。
In a study at the Yonsei University College of Medicine in South Korea, a first-of-its-kind study on pancreatic cancer, combining Ivermectin with Gemcitabine proved more effective in slowing down the cancer compared to using only Gemcitabine. This combination treatment stopped cancer cells from multiplying by blocking certain cell processes. It also made the cancer cells more likely to self-destruct while affecting their energy production and recycling systems.
韩国延世大学医学院的一项首次针对胰腺癌的研究表明，与仅使用吉西他滨相比，伊维菌素与吉西他滨的结合在减缓癌症方面更有效。这种联合治疗通过阻断某些细胞过程来阻止癌细胞增殖。它还使癌细胞更有可能自我毁灭，同时影响其能量生产和回收系统。
In tests on living organisms, the Ivermectin-Gemcitabine mix significantly reduced tumor growth compared to using only Gemcitabine.
在对活体生物体的测试中，与仅使用吉西他滨相比，伊维菌素-吉西他滨混合物显着减少了肿瘤生长。
Patient Stories: Real-life Impacts of Fenbendazole on Pancreatic Cancer
患者故事：芬苯达唑对胰腺癌的现实影响
Though anecdotal evidence is not a replacement for scientific studies, these success stories provide inspiration and hope for those battling the disease. Moreover, they serve as a motivating factor for researchers to continue exploring the potential of these repurposed medicines to their fullest extent.
尽管轶事证据不能取代科学研究，但这些成功故事为那些与疾病作斗争的人提供了灵感和希望。此外，它们也是研究人员继续最大限度地探索这些重新利用药物的潜力的激励因素。
Coralee S. shares- In August 2022, her family member was diagnosed with stage 4 pancreatic cancer, given a bleak prognosis of 3-6 months without treatment. She began taking Fenbendazole immediately but faced severe illness due to unrelated issues from tainted food. After a challenging start with chemotherapy and a decline in her quality of life, her condition notably improved while taking fenbendazole. Recent scans showed no growth or spreading of the aggressive cancer, and marker numbers dropped significantly, surprising the oncologist. Subsequent updates revealed continued positive progress, with tumor shrinkage and significantly reduced marker numbers, leading to better health and an improved quality of life.
Coralee S. 分享- 2022 年 8 月，她的家人被诊断出患有 4 期胰腺癌，如果不接受治疗，预后很暗淡，预计 3-6 个月。她立即开始服用芬苯达唑，但由于受污染的食物引起的无关问题而面临严重疾病。在经历了化疗的艰难开始和生活质量下降后，在服用芬苯达唑期间，她的病情明显改善。最近的扫描显示侵袭性癌症没有生长或扩散，并且标记物数量显着下降，这令肿瘤学家感到惊讶。随后的更新显示持续的积极进展，肿瘤缩小和标记物数量显着减少，从而改善健康状况并提高生活质量。
David Owen was diagnosed with stage IV pancreatic cancer that had also spread to his liver. Five months after starting the use of Fenbendazole along with some more supplements (similar to Joe Tippens Protocol), four of which were supplemented with chemotherapy as well… David is in remission!
大卫·欧文 (David Owen) 被诊断出患有 IV 期胰腺癌，并且已经扩散到肝脏。开始使用芬苯达唑和更多补充剂（类似于乔·蒂彭斯方案）五个月后，其中四种补充剂还辅以化疗……大卫的病情得到了缓解！